Features of ultrasound diagnosis of Ladd’s syndrome in older children
ORIGINAL PAPERS
Abstract
Introduction.The article presents an analysis of the results of ultrasound examination in older children with Ladd's syndrome. Important technical features of the ultrasound scanning technique for the most accurate detection of the “whirlpool sign” syndrome in older children are described. The sensitivity and specificity of this technique for diagnosing Ladd's syndrome in older children are presented.The aimof the study is to optimise ultrasound diagnosis of Ladd's syndrome in older children.Materials and methods.A retrospective study was conducted involving 51 older patients with verified Ladd's syndrome. All patients underwent an ultrasound examination according to a developed algorithm, which provided for the start of scanning in the epigastric region, followed by dynamic movement of the sensor in the craniocaudal direction to the left iliac region to assess the course of the mesenteric vessels throughout. The diagnosis was established in the presence of at least one primary criterion (spiral course of the small intestine or mesenteric vessels) and at least two secondary criteria (mesenteric vein dilatation, lymph node enlargement, mesenteric thickening, duodenal dilatation, pendulum-like peristalsis).Results.The developed ultrasound examination algorithm was applied to 35 (68.2%) children over one year of age and allowed verification of Ladd's syndrome in all cases, whereas the standard scanning technique proved uninformative in 29 (56%) patients in the same cohort. The method demonstrated a sensitivity of 75.5% and a specificity of 91.8%. High specificity provides a prognostic value of a positive result at the level of 95%, which makes the method highly reliable for confirming the diagnosis.Conclusion.The proposed specialised ultrasound examination algorithm is a highly effective tool for diagnosing Ladd's syndrome in older children, which significantly improves diagnostic accuracy and minimises the number of false-negative results. Its implementation in clinical practice may solve the problem of late diagnosis of this pathology.
References
1. Сварич В.Г., Каганцов И.М., Сварич В.А. Синдром Ледда у детей старшего возраста. Хирургия. Журнал им. Н.И. Пирогова. 2022;(11):61–67. https://doi.org/10.17116/hirurgia202211161. Svarich V.G., Kagantsov I.M., Svarich V.A. Ladd’s syndrome in older children. Pirogov Russian Journal of Surgery. 2022;(11):61-67. (In Russian). https://doi.org/10.17116/hirurgia202211161.
2. Svetanoff W.J., Srivatsa S., Diefenbach K., Nwomeh B.C. Diagnosis and management of intestinal rotational abnormalities with or without volvulus in the pediatric population. Semin Pediatr Surg. 2022;31(1):151141. https://doi.org/10.1016/j.sempedsurg.2022.151141.
3. Prasad G.R., Rao J.V.S., Fatima H. et al. Malrotation of midgut in adults, an unsuspected and neglected condition — An analysis of 64 consensus confirmed cases. Indian J Gastroenterol. 2015;34(6):426–430. https://doi.org/10.1007/s12664-015-0596-x.
4. Саттаров Ж.Б., Эргашев Н.Ш. Выбор хирургической тактики при мальротации кишечника у детей. Современная медицина: актуальные вопросы. 2015;12(44):90–99. Sattarov J.B., Ergashev N.Sh. The choice of surgical tactics at malrotation intestine at children. Sovremennaya meditsina: aktualnyye voprosy. 2015;12(44):90–99. (In Russian).
5. Nagdeve N.G., Qureshi A.M., Bhingare P.D., Shinde S.K. Malrotation beyond infancy. J Pediatr Surg. 2012;47(11):2026–2032. https://doi.org/10.1016/j.jpedsurg.2012.06.013.
6. Husberg B., Salehi K., Peters T., Gunnarsson U., Michane M., Nordenskjöld, A., Strigård, K. Congenital intestinal malrotation in adolescent and adult patients: a 12-year clinical and radiological survey. Springer Plus. 2016;(5):1–7. https://doi.org/10.1186/s40064-016-1842-0.
7. Applegate K.E. Evidence-based diagnosis of malrotation and volvulus. Pediatric radiology. 2009;39:161. https://doi.org/10.1007/s00247-009-1177-x.
8. Gilbertson-Dahdal D.L., Dutta S., Varich L.J., Barth R.A. Neonatal malrotation with midgut volvulus mimicking duodenal atresia. Am J Roentgenol. 2009;192(5):1269–1271. https://doi.org/10.2214/AJR.08.2132.
9. Alessandri G., Amodio A., Landoni L., De’Liguori Carino N., Bassi C. Recurrent acute pancreatitis in bowel malrotation. Eur Rev Med Pharmacol Sci. 2016;20(22):4719-4724.
10. Maxson R.T., Franklin P.A., Wagner C.W. Malrotation in the older child: surgical management, treatment, and outcome Am Surg. 1995;61(2):135–138.
11. Zissin R., Rathaus V., Oscadchy A., Kots E., Gayer G., Shapiro-Feinberg, M. (1999). Intestinal malrotation as an incidental finding on CT in adults. Abdominal imaging. 1990;24(6);550–555. https://doi.org/10.1007/s002619900560.
12. Michalopoulos A., Papadopoulos V., Paramythiotis D., Papavramidis T., Douros V., Netta S., Apostolidis S. Colonic cancer in a patient with intestinal malrotation: a case report. Tech Coloproctol. 2010;14(Suppl 1);S65–66. https://doi.org/10.1007/s10151-010-0632-x.
13. Palepu R.P., Harmon C.M., Goldberg S.P., Clements R.H. Intestinal malrotation discovered at the time of laparoscopic Roux-en-Y gastric bypass. J Gastrointest Surg. 2007;11(7):898–902. https://doi.org/10.1007/s11605-006-0035-5.
14. Ren P.-T., Lu B.-C. Intestinal malrotation associated with colon cancer in an adult: report of a case. Surg Today. 2009;39(7):624–627. https://doi.org/10.1007/s00595-008-3913-5.
15. Кучеров Ю.И., Фатеев Ю.Е., Голоденко Н.В., Романова Л.А., Левитская М.В. Ультразвуковая диагностика синдрома Ледда у детей. Детская хирургия. 2003;(6):52–53. Kucherov Yu.I., Fateev Yu.E., Golodenko N.V., Romanova L.A., Levitskaya M.V. Ultrasound diagnostics of Ladd’s syndrome in children. Pediatric surgery. 2003;(6):52–53.
16. Sasaki T., Soh H., Kimura T., Hasegawa T., Okada A., Fukuzawa M. Recurrent acute pancreatitis caused by malrotation of the intestine and effective treatment with laparoscopic Ladd’s procedure. Pediat Surg Int. 2005;21(12):994–996. https://doi.org/10.1007/s00383-005-1466-x.
17. Arunachalam R. Malrotation and abdominal pain: A diagnosis eluding the unprepared mind. Indian J Gastroenterol. 2015;34(6):415–417. https://doi.org/10.1007/s12664-015-0615-y.
18. Jiménez-Fuertes M., Costa-Navarro D., Zamora-Amorós C. Abdominal pain and intestinal malrotation in adults. Rev Esp Enferm Dig. 2013;105;105–106. https://doi.org/10.4321/s1130-01082013000200008.
19. Katz M.E., Siegel M.J., Shackelford G.D., Mc Alister W.H. The position and mobility of the duodenum in children. Am J Roentgenol. 1987;148(5):947–951. https://doi.org/10.2214/ajr.148.5.947.
20. Chandra J., Grierson C., Bungay H. Normal variations in pancreatic contour are associated with intestinal malrotation and can mimic neoplasm. Clinical radiology. 2012;67(12):1187–1192. https://doi.org/10.1016/j.crad.2011.11.021.
21. Fang K., Liu Q., Corden M. Malrotation with volvulus presenting as recurrent pancreatitis. Official journal of the American College of Gastroenterology. ACG. 2015:110:S402–S403.
22. Субботин И.В., Холостова В.В., Смирнов А.Н., Аль-Машат Н.А., Ярустовский П.М., Дехконбоев А.А., Ахмаджонов А.М., Сытьков В.В., Хавкин А.И. Клинический случай синдрома Ледда в подростковом возрасте. Children’s Medicine of the North-West. 2024;12(3):158–162. https://doi.org/10.56871/ Cm N-W.2024.52.77.019. Subbotin I.V., Kholostova V.V., Smirnov A.N., Al-Mashat N.A., Yarustovskiy P.M., Dehkonboev А.А., Akhmadjonov A.M., Sytkov V.V., Khavkin A.I. Clinical case of Ledd’s syndrome in adolescence. Children’s Medicine of the North-West. 2024;12(3):158–162. https://doi.org/10.56871/Cm N-W.2024.52.77.019.
23. Старков Ю.Г., Солодинина Е.Н., Домарев Л.В., Алексеев К.И. Новые методы диагностики заболеваний тонкой кишки. Капсульная эндоскопия и двухбаллонная интестиноскопия. Медицинская визуализация. 2026;(3):65–74. Starkov Yu.G., Solodinina E.N., Domarev L.V., Alekseev K.I. New modalities of diagnosis of small intestine diseases — capsule endoscopy and double balloon intestinoscopy. Medical Visualization. 2006;(3):65–74.
24. Детская гастроэнтерология. Национальное руководство. С.В. Бельмер, А.Ю. Разумовский, А.И. Хавкин, ред. М.: ГЭОТАР-Медиа; 2022. Children’s gastroenterology. National leadership. S.V. Belmer, A.Yu. Razumovsky, A.I. Khavkin, ed. Moscow: GEOTAR-Media; 2022.
25. Болезни кишечника у детей. С.В. Бельмер, А.Ю. Разумовский, А.И. Хавкин, ред. Т. 1. М.: Медпрактика-М; 2018. Intestinal diseases in children. S.V. Belmer, A.Yu. Razumovsky, A.I. Khavkin, eds. Vol. 1. Moscow: Medpraktika-M; 2018.
26. Filion L., Beaunoyer M., Miron M.C., Blondin S.E., Tourigny-Ruel G., Trottier E.D., Assaad M.A. Infant malrotation with midgut volvulus: A retrospective review of clinical presentation and delays in care at a Canadian tertiary paediatric centre. Paediatr Child Health. 2025;30(6):453–458. https://doi.org/10.1093/pch/pxaf042.
27. Menghwani H., Piplani R., Yhoshu E., Jagdish B., Sree B.S. Delayed presentation of malrotation: case series and literature review. J Indian Assoc Pediatr Surg. 2023;28(4):271–277. https://doi.org/10.4103/jiaps.jiaps_2_23.



