Пептическая функция желудка у детей с ожирением: ОРИГИНАЛЬНЫЕ СТАТЬИ

Полина Андреевна  Панкратова; Валерия Павловна  Новикова; Александр Евгеньевич  Блинов; Ольга Николаевна  Варламова; Ольга Петровна  Гурина; Нина Викторовна  Евдокимова; Анастасия Павловна  Листопадова

doi:10.56871/

Peptic function of stomach in children with obesity

ORIGINAL PAPERS

Polina A. Pankratova Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-9029-2312
Valeria P. Novikova Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-0992-1709
Aleksandr E. Blinov Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-2895-7379
Olga N. Varlamova Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-2195-0756
Olga P. Gurina Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-1066-5423
Nina V. Evdokimova Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0001-9812-6899
Anastasia P. Listopadova Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0001-5220-3414

Keywords:

gastrin childhood obesity pepsinogen Helicobacter pylori Gastro Panel Biohit гастрин детское ожирение пепсиноген Helicobacter pylori Gastro Panel Biohit

Abstract

Introduction.Obesity affects various parts of the gastrointestinal tract in both children and adults.The stomach can be considered both a target organ for obesity and as a predictor of the development of obesity, since it affects appetite through the secretion of gastric hormones.Aim— to study the features of gastric peptic function in children with obesity using a non-invasive method.Materials and methods. A total of 109 children aged 2–17 years were examined, of which 67 had obesity (body mass index >2 SD) and 42 had normal body mass index. All patients underwent an assessment of peptic function using the Gastro Panel Biohit kit for non-morphological diagnosis of gastric conditions (pepsinogen I, pepsinogen II, gastrin-17, Ig G antibodies toH. pyloriin blood plasma) and determination of Ig G antibody titres to H+/K+-ATPase of gastric parietal cells in blood serum usingby enzyme immunoassay (ELISA). The normal level of antibodies to H+/K+-ATPase is no more than 20 U/ml. Interpretation of Gastro Panel Biohit results was carried out using the Gastro Soft program.Results. In children with obesity, decreased levels of pepsinogen I, pepsinogen II, and gastrin in blood plasma were detected, with a normal pepsinogen I/pepsinogen II ratio, compared to children with normal body weight. The level of Ig G antibodies to
H+/K+-ATPase of gastric parietal cells in blood serum showed no significant differences between the groups. In the presence of seropositivity forH. pyloriin both groups, pepsinogen and gastrin levels were higher, but no significant intergroup differences were found.Conclusion. Obesity in children is accompanied by a decrease in gastric peptic activity while maintaining the pepsinogen ratio. The effect ofH. pylorion peptic function was similar in children with and without obesity: pepsinogen and gastrin levels were higher in cases ofH. pyloriinfection. The potential of Gastro Panel Biohit for early diagnosis of decreased gastric peptic function in children with obesity requires further study.

Author Biographies

Polina A. Pankratova, Saint Petersburg State Pediatric Medical University

Assistant Professor, Department of Propaedeutics of Childhood Diseases with a Course in General Child Care

Valeria P. Novikova, Saint Petersburg State Pediatric Medical University

Dr. Sci. (Med.), Professor, Head of Department of Propaedeutics of Childhood Diseases with a Course in General Child Care, Head of the Laboratory of Medical and Social Problems in Pediatrics

Aleksandr E. Blinov, Saint Petersburg State Pediatric Medical University

Senior Researcher, Laboratory of Medical and Social Problems in Pediatrics, Research Center

Olga N. Varlamova, Saint Petersburg State Pediatric Medical University

Senior Researcher, Laboratory of Medical and Social Problems in Pediatrics, Research Center

Olga P. Gurina, Saint Petersburg State Pediatric Medical University

Cand. Sci. (Med.), Senior Researcher, Laboratory of Medical and Social Problems in Pediatrics, Research Center

Nina V. Evdokimova, Saint Petersburg State Pediatric Medical University

Cand. Sci. (Med.), Associate Professor, Department of Propaedeutics of Childhood Diseases with a Course in General Child Care

Anastasia P. Listopadova, Saint Petersburg State Pediatric Medical University

Cand. Sci. (Med.), Associate Professor, Department of Propaedeutics of Childhood Diseases with a Course in General Child Care

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Peptic function of stomach in children with obesity: ORIGINAL PAPERS. (2026). Children’s Medicine of the North-West, 13(4), 227-236. https://doi.org/10.56871/

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Peptic function of stomach in children with obesity: ORIGINAL PAPERS. (2026). Children’s Medicine of the North-West, 13(4), 227-236. https://doi.org/10.56871/

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