The significance of microcirculation disorders and changes in blood rheological characteristics for the development of inflammatory bowel diseases
GASTROENTEROLOGY AND DIETOLOGY
Abstract
The review provides an analysis of literature data on changes in the blood microcirculation system at inflammatory bowel diseases and their impact on the development of general disorders in the body.It explores the consequences of damage to the inner lining of blood vessels (endothelium) and the slowdown in capillary blood flow. These processes are being studied because the hemostasis system and blood fluidity (haemorheology) ensure normal blood supply to tissues, and when these systems are disrupted, perfusion is severely impaired. An analysis of scientific data allows us to draw a clear conclusion: disruptions in microcirculation and a decrease in blood fluidity, primarily due to increased clumping of red blood cells and a loss of their flexibility, play a crucial role in the development of inflammatory bowel diseases. These abnormalities create a vicious cycle: the worse the blood supply to tissues, the more pronounced the tissue ischemia is, and the more severe the inflammation is. This combination causes the disease to worsen.
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