Персонифицированная коррекция саркопении у детей с нутритивной недостаточностью: результаты пятилетнего катамнеза: ГАСТРОЭНТЕРОЛОГИЯ И ДИЕТОЛОГИЯ

Милена Николаевна  Яковлева; Валерия Павловна  Новикова; Анна Николаевна  Завьялова; Ирина Сергеевна  Новикова; Мария Николаевна  Качалова

doi:10.56871/

Personalized correction of sarcopenia in children with nutritional insufficiency: results of a five-year follow-up

GASTROENTEROLOGY AND DIETOLOGY

Milena N. Yakovleva Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0001-8986-7599
Valeria P. Novikova Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-0992-1709
Anna N. Zavyalova Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-9532-9698
Irina S. Novikova Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-2979-8231
Maria N. Kachalova Saint Petersburg State Pediatric Medical University; Social Services House “Vmeste” https://orcid.org/0009-0009-4101-5958

Keywords:

sarcopenia children nutritional insufficiency dysphagia enteral nutrition metabolic therapy follow-up cerebral palsy саркопения дети нутритивная недостаточность дисфагия энтеральное питание метаболическая терапия катамнез детский церебральный паралич

Abstract

Introduction.Sarcopenia in children with nutritional insufficiency is associated with an unfavorable prognosis, yet effective treatment strategies and optimal follow-up duration remain uncertain. This study presents the results of a 5-year follow-up of patients receiving personalized correction.Aim— to evaluate the effectiveness of a personalized algorithm for the correction of sarcopenia in children with nutritional insufficiency based on the results of a 5-year follow-up.Materials and methods.The follow-up group included 18 patients (all girls) with sarcopenia against the background of nutritional insufficiency: 17 with cerebral palsy (GMFCS (Gross Motor Function Classification System) levels III–V) and 1 with Crohn’s disease. The median age at the time of diagnosis was 9.0 [7.0; 13.0] years. The follow-up duration was 5 years. Treatment included correction of dysphagia, individualized selection of enteral nutrition (polymeric, semi-elemental formulas), metabolic therapy (vitamins B1, B6, B12, E, D) and probiotics. Effectiveness was assessed by body composition dynamics (bioelectrical impedance analysis) and anthropometry.Results.Resolution of sarcopenia was achieved in 13 (72.2%) patients. The median time to resolution was 4.0 years (95% CI 2.1–5.9), mean time — 3.6 years (95% CI 2.8–4.3). Dysphagia correction (nasogastric tube or gastrostomy placement) and metabolic therapy significantly improved outcomes (p=0.004 and p=0.041, respectively). Transition to extensively hydrolyzed protein formulas did not affect the rate of sarcopenia resolution (p=0.794).Conclusion.Personalized correction of sarcopenia including dysphagia management, nutritional support and metabolically oriented vitamin therapy allows sarcopenia resolution in 72.2% of children with nutritional insufficiency with a follow-up duration of at least 3.5 years.

Author Biographies

Milena N. Yakovleva, Saint Petersburg State Pediatric Medical University

pediatrician, nutritionist, assistant, Department of Propaedeutics of Childhood Diseases with a course in general child care named after V.V. Yuryev

Valeria P. Novikova, Saint Petersburg State Pediatric Medical University

Dr. Sci. (Med.), Professor, Head of the Department of Propaedeutics of Childhood Diseases with a Course in General Child Care named after V.V. Yuryev

Anna N. Zavyalova, Saint Petersburg State Pediatric Medical University

Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Childhood Diseases with a Course in General Child Care named after V.V. Yuryev

Irina S. Novikova, Saint Petersburg State Pediatric Medical University

infectious disease specialist, pediatrician, assistant, Department of Propaedeutics of Childhood Diseases with a course in general child care named after V.V. Yuryev

Maria N. Kachalova, Saint Petersburg State Pediatric Medical University; Social Services House “Vmeste”

Pediatrician, Head of the palliative care department Social Services House “Vmeste”; Laboratory Assistant, Department of Propaedeutics of Pediatric Diseases with a Course in General Child Care

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Personalized correction of sarcopenia in children with nutritional insufficiency: results of a five-year follow-up: GASTROENTEROLOGY AND DIETOLOGY. (2026). Children’s Medicine of the North-West, 14(2), 147-156. https://doi.org/10.56871/

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Personalized correction of sarcopenia in children with nutritional insufficiency: results of a five-year follow-up: GASTROENTEROLOGY AND DIETOLOGY. (2026). Children’s Medicine of the North-West, 14(2), 147-156. https://doi.org/10.56871/

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