Качество жизни детей с функциональными расстройствами органов пищеварения с абдоминальной болью: одномоментное исследование: ГАСТРОЭНТЕРОЛОГИЯ И ДИЕТОЛОГИЯ

Нурали Зоирович Зокиров; Эльмира Ибрагимовна Алиева; Арсений Викторович Краснов; Анатолий Ильич Хавкин; Валентин Вячеславович Сытьков

doi:10.56871/

Quality of life of children with functional abdominal pain disorders: a cross-sectional study

GASTROENTEROLOGY AND DIETOLOGY

Nurali Z. Zokirov Federal Scientiﬁ c and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency of Russia; State Scientiﬁ c Center of the Russian Federation — A.I. Burnazyan Federal Medical Biophysical Center; Academy of Postgraduate Education of the Federal Scientiﬁ c and Clinical Center of the Federal Medical and Biological Agency of Russia https://orcid.org/0000-0002-1928-749X
Elmira I. Alieva Federal Scientifi c and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency of Russia; State Scientifi c Center of the Russian Federation — A.I. Burnazyan Federal Medical Biophysical Center; Academy of Postgraduate Education of the Federal Scientifi c and Clinical Center of the Federal Medical and Biological Agency of Russia https://orcid.org/0009-0001-5863-1556
Arseniy V. Krasnov Academy of Postgraduate Education of the Federal Scientifi c and Clinical Center of the Federal Medical and Biological Agency of Russia; Dolgoprudny Central City Hospital https://orcid.org/0009-0001-4112-9244
Anatoly I. Khavkin Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region; Belgorod State National Research University https://orcid.org/0000-0001-7308-7280
Valentin V. Sytkov Federal Scientifi c and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency of Russia; Russian University of Medicine https://orcid.org/0000-0001-6152-5693

Keywords:

functional gastrointestinal disorders abdominal pain functional dyspepsia irritable bowel syndrome biliary dysfunction functional abdominal pain quality of life Peds QL функциональные расстройства органов пищеварения боль в животе функциональная диспепсия синдром раздраженного кишечника билиарная дисфункция функциональная абдоминальная боль качество жизни Peds QL

Abstract

Introduction.Functional abdominal pain disorders are widespread in pediatric practice and have a significant impact on the quality of life of patients.Aim— to evaluate the quality of life of children aged 8–17 years with functional abdominal pain disorders compared to healthy peers.Materials and methods.A one-stage study was conducted with the participation of 193 children with functional abdominal pain disorders (functional dyspepsia, irritable bowel syndrome, functional abdominal pain, biliary dysfunction) aged 8–17 years and 183 healthy children (control group). The quality of life was assessed using the Russian version of the Peds QL 4.0 questionnaire. Nonparametric methods and a generalized linear model adjusted for age and gender were used for statistical analysis.Results.Children with functional abdominal pain disorders demonstrated a significantly lower overall quality of life compared to healthy peers (69.6 vs. 85.9; p <0.001). A decrease in scores was observed in all quality of life domains: physical activity (71.9 vs. 87.5 in the control group) and psychosocial functioning (68.3 vs. 83.3) were significantly lower in the functional abdominal pain disorders group. The school functioning scale was the most significantly affected (65.0 vs. 80.0; p <0.001). In the functional abdominal pain disorders group, lower quality of life scores were associated with female gender and adolescence (13–17 years). A generalized linear model confirmed that the presence of functional abdominal pain disorders was the most powerful independent predictor of lower quality of life.Healthy children had higher quality of life by 12.34 points (B=12.34, p <0.001), after adjusting for gender and age.Conclusion.The presence of functional abdominal pain disorders is associated with a significant decrease in the quality of life in children. Adolescents and girls with functional abdominal pain disorders represent the most vulnerable groups. Comprehensive management of such patients should be aimed not only at relieving pain, but also at improving the quality of life.

Author Biographies

Nurali Z. Zokirov, Federal Scientiﬁ c and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency of Russia; State Scientiﬁ c Center of the Russian Federation — A.I. Burnazyan Federal Medical Biophysical Center; Academy of Postgraduate Education of the Federal Scientiﬁ c and Clinical Center of the Federal Medical and Biological Agency of Russia

Dr. Sci. (Med.), Professor, Head of the Nephrology Department; Professor, Head of the Department of Pediatrics, Academy of Postgraduate Education, Federal Scientific and Clinical Center for Children and Adolescents, Federal Medical and Biological Agency of Russia; Professor, Department of Pediatrics, State Scientific Center of the Russian Federation —
A.I. Burnazyan Federal Medical Biophysical Center, Federal Medical and Biological Agency of Russia.

Elmira I. Alieva, Federal Scientifi c and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency of Russia; State Scientifi c Center of the Russian Federation — A.I. Burnazyan Federal Medical Biophysical Center; Academy of Postgraduate Education of the Federal Scientifi c and Clinical Center of the Federal Medical and Biological Agency of Russia

Dr. Sci. (Med.), Professor, Department of Pediatrics, Federal Scientific and Clinical Center for Children and Adolescents, Federal Medical and Biological Agency of Russia; Professor, Department of Pediatrics, State Scientific Center of the Russian Federation — A.I. Burnazyan Federal Medical Biophysical Center, Federal Medical and Biological Agency of Russia.

Arseniy V. Krasnov, Academy of Postgraduate Education of the Federal Scientifi c and Clinical Center of the Federal Medical and Biological Agency of Russia; Dolgoprudny Central City Hospital

Postgraduate Student, Department of Pediatrics, Federal Scientific and Clinical Center for Children and Adolescents, Federal Medical and Biological Agency of Russia; District Pediatrician, Dolgoprudny Clinical Hospital, Moscow Region.

Anatoly I. Khavkin, Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region; Belgorod State National Research University

Dr. Sci. (Med.), Professor,
Head of the Moscow Regional Center of Pediatric
Gastroenterology and Hepatology of the Research Clinical
Institute of Childhood; Professor, Department of Pediatrics
with a Course in Pediatric Surgical Diseases of the Medical Institute of the Belgorod National Research University.

Valentin V. Sytkov, Federal Scientifi c and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency of Russia; Russian University of Medicine

Cand. Sci. (Med.),Associate Professor, Department of Pediatric Surgery.

References

1. Новик А.А., Ионова Т.И. Руководство по исследованию качества жизни в медицине. Ю.А. Шевченко, ред. 4-е изд., перераб. и доп. М.: Изд-во НМХЦ им Н.И. Пирогова; 2021.

2. Агрба А.В., Ильдарова А.А., Стеценко М.С. Значение использования опросников качества жизни при оценке эффективности терапии детей с хронической гастродуоденальной патологией. В кн.: Современное животноводство и инновации в технологии производства продуктов питания, аспекты экологической, производственной и гигиенической безопасности. Материалы международной научно-практической конференции. Персиановский, 22 ноября 2024 года. Персиановский: Донской государственный аграрный университет; 2024. С. 472–478. EDN: WFKXUC.

3. Rajmil L., López A.R., López-Aguilà S., Alonso J. Parent-child agreement on health-related quality of life (HRQOL): a longitudinal study. Health Qual Life Outcomes. 2013;11:1–10. https:/doi.org/10.1186/1477-7525-11-101.

4. Arsiwala T., Afroz N., Kordy K., Naujoks C., Patalano F. Measuring what matters for children: a systematic review of frequently used pediatric generic PRO instruments. Ther Innov Regul Sci. 2021;55(5):1082–1095. https:/doi.org/10.1007/s43441-021-00311-x. 5. Varni J.W., Seid M., Rode C.A. The Peds QL™: measurement model for the pediatric quality of life inventory. Med Care.1999;37(2):126–139.

6. Силонян А.Л., Сурков А.Н., Черников В.В. Качество жизни детей с воспалительными заболеваниями кишечника. Российский педиатрический журнал. 2021;24(S):55–56. EDN: OMDRWB.

7. Аракелян Л., Сурков А.Н., Намазова-Баранова Л.С. и др. Оценка качества жизни детей с воспалительными заболеваниями кишечника. University Therapeutic Journal.2024;6(S2):9–10. EDN: IAKZIA.

8. Тагирова А.Р. Качество жизни у детей с воспалительными заболеваниями кишечника. Дис. … канд. мед. наук. М.; 2021. 177 с. EDN: PRFIQL.

9. Свидетельство о государственной регистрации программы для ЭВМ № 2024615192 Российская Федерация. Намазова-Баранова Л.С., Сурков А.Н., Бессонов Е.Е. и др. Программа для мониторинга состояния пациентов детского возраста с патологией органов желудочно-кишечного тракта: № 2024613598: заявл. 20.02.2024: опубл. 04.03.2024; заявитель Федеральное государственное бюджетное научное учреждение «Российский научный центр хирургии имени академика Б.В. Петровского». EDN: IKNWLL.

10. Varni J.W., Bendo C.B., Denham J. et al. Peds QL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases in comparison to healthy controls. Qual Life Res. 2015;24(2):363–378. https:/doi.org/10.1007/s11136-014-0781-x.

11. Бельмер С.В., Волынец Г.В., Горелов А.В., Гурова М.М., Звягин А.А. и др. Функциональные расстройства органов пищеварения у детей. Рекомендации Общества детских гастроэнтерологов, гепатологов и нутрициологов. Часть 1. Российский вестник перинатологии и педиатрии. 2020;65(4):150–161. https:/doi.org/10.21508/1027-4065-2020-65-4-150-161.

12. Бельмер С.В., Волынец Г.В., Горелов А.В., Гурова М.М., Звягин А.А. и др. Функциональные расстройства органов пищеварения у детей. Рекомендации Общества детских гастроэнтерологов, гепатологов и нутрициологов. Часть 2. Российский вестник перинатологии и педиатрии. 2020;65(5):100–111. https://doi.org/10.21508/1027-4065-2020-65-5-100-111.

13. Бельмер С.В., Волынец Г.В., Горелов А.В., Гурова М.М., Звягин А.А. и др. Функциональные расстройства органов пищеварения у детей. Рекомендации Общество детских гастроэнтерологов, гепатологов и нутрициологов. Часть 3. Российский вестник перинатологии и педиатрии. 2020;65(6):133–144. https://doi.org/10.21508/1027-4065-2020-65-6-133-144.

14. Детская гастроэнтерология. Национальное руководство. Бельмер С.В., Разумовский А.Ю., ред. М.: ГЭОТАР-Медиа; 2022. 864 с.

15. Зокиров Н.З., Алиева Э.И., Краснов А.В., Сытьков В.В., Яблокова Е.А. Распространенность функциональных расстройств органов пищеварения с абдоминальной болью у детей в возрасте 8–17 лет: поперечное исследование. Педиатрическая фармакология. 2025;22(6):655–662. https://doi.org/10.15690/pf.v22i6.2991.

16. Karami H. et al. Quality of life for children with functional abdominal pain and their parents copmared to healthy individuals. J Ped Rev. 2022;10(3):267–272. https://doi.org/0.32598/jpr.10.3.1018.1.

17. Поливанова Т.В., Каспаров Э.В., Вшивков В.А. Показатели качества жизни школьников с болями в животе. Экспериментальная и клиническая гастроэнтерология. 2023;1(209):158–164. https://doi.org/10.31146/1682-8658-ecg-209-1-158-164. E D N : T L Q T G P.

Quality of life of children with functional abdominal pain disorders: a cross-sectional study: GASTROENTEROLOGY AND DIETOLOGY. (2026). Children’s Medicine of the North-West, 14(1), 74-86. https://doi.org/10.56871/

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Quality of life of children with functional abdominal pain disorders: a cross-sectional study: GASTROENTEROLOGY AND DIETOLOGY. (2026). Children’s Medicine of the North-West, 14(1), 74-86. https://doi.org/10.56871/

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